Cities across China are making huge investments in order to transform themselves into world-class innovation hubs. So far, the Pearl River Delta Greater region, led by Shenzhen, Guangzhou and Hong Kong, is the most promising area. Connected by high-speed railways and land bridges, barriers between Hong Kong and mainland have been removed. With Hong Kong as the financial hub, Shenzhen as the innovation center and Guangzhou as the long-term trade harbor, China’s “Greater Bay Area” is taking shape. Will the regional integration create a new innovation engine that China urgently needs?